The 2,300-square-foot renovated house features century-old oak floors, three bedrooms and 21/2 bathrooms. Custom-built sliding doors lead to multiple decks, an outdoor fireplace and sitting areas. There is a chicken coop, a horse corral, an organic garden and fruit trees on the gated lot.
Spelling, 39, played Donna Martin in "Beverly Hills, 90210" (1990-2000) and reprised the role in "90210" (2009).
McDermott, 45, played Constable Turnbull on "Due South" (1997-99) and appeared on the crime drama "1-800-Missing" (2003-04).
The couple, who have starred together on several of their own reality shows, had their fourth baby in August.
Public records show the couple bought the property last year for $2.4 million. They listed it in April at $2.675 million.
Madison Hildebrand of Coldwell Banker's Malibu Colony office was the listing agent. Elizabeth M. Walton of Keller Williams in Pacific Palisades represented the buyer.
Follow me on Twitter: @LATHotProperty